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Coats, tethers, Rabs, and SNAREs work together to mediate the intracellular destination of a transport vesicle Cai H; Reinisch K; Ferro-Novick SDev Cell 2007[May]; 12 (5): 671-82Tethering factors have been shown to interact with Rabs and SNAREs and, more recently, with coat proteins. Coat proteins are required for cargo selection and membrane deformation to bud a transport vesicle from a donor compartment. It was once thought that a vesicle must uncoat before it recognizes its target membrane. However, recent findings have revealed a role for the coat in directing a vesicle to its correct intracellular destination. In this review we will discuss the literature that links coat proteins to vesicle targeting events.|Animals[MESH]|Biological Transport[MESH]|Coatomer Protein/*metabolism[MESH]|Humans[MESH]|Protein Subunits/metabolism[MESH]|SNARE Proteins/*metabolism[MESH]|Transport Vesicles/*metabolism[MESH]|rab GTP-Binding Proteins/*metabolism[MESH] |
