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lüll T-cadherin suppresses angiogenesis in vivo by inhibiting migration of endothelial cells Rubina K; Kalinina N; Potekhina A; Efimenko A; Semina E; Poliakov A; Wilkinson DG; Parfyonova Y; Tkachuk VAngiogenesis 2007[]; 10 (3): 183-95Our previous studies have revealed the abundant expression of T-cadherin--a glycosylphosphatidylinositol (GPI)-anchored member of cadherin superfamily--in endothelial and mural cells in the heart and vasculature. The upregulation of T-cadherin in vascular proliferative disorders such as atherosclerosis and restenosis suggests the involvement of T-cadherin in vascular growth and remodeling. However, the functional significance of this molecule in the vasculature remains unknown. The effect of T-cadherin on angiogenesis in vivo was evaluated using Matrigel implant model. We demonstrate that T-cadherin overexpression in L929 cells injected in Matrigel inhibits neovascularization of the plug. In vitro T-cadherin inhibits the directional migration of endothelial cells, capillary growth, and tube formation but has no effect on endothelial cell proliferation, adhesion, or apoptosis in vitro. These data suggest that T-cadherin expressed in the stroma could act as a negative guidance cue for the ingrowing blood vessels and thus could have an important potential therapeutic application.|Animals[MESH]|Biomarkers/metabolism[MESH]|Cadherins/genetics/metabolism/pharmacology/*physiology[MESH]|Cell Line[MESH]|Cell Movement/*drug effects[MESH]|Cells, Cultured[MESH]|Collagen/metabolism[MESH]|Culture Media, Conditioned/pharmacology[MESH]|Drug Combinations[MESH]|Endothelial Cells/cytology/*physiology[MESH]|Endothelium, Vascular/cytology[MESH]|Fluorescent Antibody Technique, Direct[MESH]|Humans[MESH]|Kidney/cytology[MESH]|L Cells[MESH]|Laminin/metabolism[MESH]|Mice[MESH]|Mice, Nude[MESH]|Models, Biological[MESH]|Neoplasm Transplantation[MESH]|Neovascularization, Physiologic/drug effects/*physiology[MESH]|Platelet Endothelial Cell Adhesion Molecule-1/metabolism[MESH]|Proliferating Cell Nuclear Antigen/metabolism[MESH]|Proteoglycans/metabolism[MESH]|Transplantation, Homologous[MESH]|Umbilical Veins/cytology[MESH] |