Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17482892&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Human variants of O6-alkylguanine-DNA alkyltransferase Pegg AE; Fang Q; Loktionova NADNA Repair (Amst) 2007[Aug]; 6 (8): 1071-8This article summarizes the current understanding of known variant forms of the MGMT gene that encode an altered protein. Epidemiological studies have been carried out to test whether these alterations are associated with altered cancer risk. Laboratory studies using recombinant proteins and cells expressing the known variants have investigated the possible effects of these sequence alterations on the ability of the encoded O(6)-alkylguanine-DNA alkyltransferase protein to protect cells from alkylation damage and to respond to therapeutic inactivators currently undergoing trials for cancer chemotherapy.|*Genetic Variation[MESH]|Amino Acid Substitution[MESH]|DNA Modification Methylases/*genetics/metabolism[MESH]|DNA Repair[MESH]|DNA Repair Enzymes/*genetics/metabolism[MESH]|Female[MESH]|Gene Expression[MESH]|Humans[MESH]|In Vitro Techniques[MESH]|Male[MESH]|Neoplasms/enzymology/genetics[MESH]|O(6)-Methylguanine-DNA Methyltransferase/*genetics/metabolism[MESH]|Polymorphism, Single Nucleotide[MESH]|Recombinant Proteins/genetics/metabolism[MESH]|Tumor Suppressor Proteins/*genetics/metabolism[MESH] |
