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lüll MGMT: a personal perspective Mitra SDNA Repair (Amst) 2007[Aug]; 6 (8): 1064-70This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.|*O(6)-Methylguanine-DNA Methyltransferase/genetics/history[MESH]|Alkylating Agents/toxicity[MESH]|Animals[MESH]|Cloning, Molecular[MESH]|DNA Modification Methylases/genetics/history[MESH]|DNA Repair[MESH]|DNA Repair Enzymes/genetics/history[MESH]|Escherichia coli/drug effects/genetics/metabolism[MESH]|Guanine/analogs & derivatives/chemistry[MESH]|History, 20th Century[MESH]|History, 21st Century[MESH]|Humans[MESH]|Methylnitronitrosoguanidine/toxicity[MESH]|Mutation[MESH]|Tumor Suppressor Proteins/genetics/history[MESH] |