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  • MGMT: a personal perspective
  • Mitra S
  • DNA Repair (Amst) 2007[Aug]; 6 (8): 1064-70
  • This review describes the history of studies on alkylation damage of mammalian genomes and its carcinogenic consequences that led to the discovery of a unique DNA repair protein, named MGMT. MGMT repairs O(6)-alkylguanine, a critical mutagenic lesion induced by alkylating agents. The follow-up studies in mammalian cells following the discovery of the ubiquitous repair protein in E. coli are summarized.
  • |*O(6)-Methylguanine-DNA Methyltransferase/genetics/history[MESH]
  • |Alkylating Agents/toxicity[MESH]
  • |Animals[MESH]
  • |Cloning, Molecular[MESH]
  • |DNA Modification Methylases/genetics/history[MESH]
  • |DNA Repair[MESH]
  • |DNA Repair Enzymes/genetics/history[MESH]
  • |Escherichia coli/drug effects/genetics/metabolism[MESH]
  • |Guanine/analogs & derivatives/chemistry[MESH]
  • |History, 20th Century[MESH]
  • |History, 21st Century[MESH]
  • |Humans[MESH]
  • |Methylnitronitrosoguanidine/toxicity[MESH]
  • |Mutation[MESH]
  • |Tumor Suppressor Proteins/genetics/history[MESH]





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    *<b>[http://www.kidney.de/mlpefetch.php?search=17482889 MGMT: a personal perspective ]</b> DNA Repair (Amst) 2007; 6(8) ; 1064-70 Mitra S

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    DNA Repair (Amst)

    1064 8.6 2007