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lüll Endogenous synthesis of coenzyme Q in eukaryotes Tran UC; Clarke CFMitochondrion 2007[Jun]; 7 Suppl (Suppl): S62-71Coenzyme Q (Q) functions in the mitochondrial respiratory chain and serves as a lipophilic antioxidant. There is increasing interest in the use of Q as a nutritional supplement. Although, the physiological significance of Q is extensively investigated in eukaryotes, ranging from yeast to human, the eukaryotic Q biosynthesis pathway is best characterized in the budding yeast Saccharomyces cerevisiae. At least ten genes (COQ1-COQ10) have been shown to be required for Q biosynthesis and function in respiration. This review highlights recent knowledge about the endogenous synthesis of Q in eukaryotes, with emphasis on S. cerevisiae as a model system.|Animals[MESH]|Antioxidants/metabolism[MESH]|Caenorhabditis elegans/metabolism[MESH]|Carbon/chemistry[MESH]|Eukaryotic Cells/metabolism[MESH]|Gene Expression Regulation, Enzymologic[MESH]|Humans[MESH]|Lipids/chemistry[MESH]|Mitochondria/metabolism[MESH]|Models, Biological[MESH]|Models, Chemical[MESH]|Protein Transport[MESH]|Saccharomyces cerevisiae/metabolism[MESH]|Ubiquinone/*biosynthesis/*chemistry/metabolism[MESH] |