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Roles of cyclic diguanylate in the regulation of bacterial pathogenesis Tamayo R; Pratt JT; Camilli AAnnu Rev Microbiol 2007[]; 61 (ä): 131-48Cyclic diguanylate (c-di-GMP) is a bacterial second messenger of growing recognition involved in the regulation of a number of complex physiological processes. This review describes the biosynthesis and hydrolysis of c-di-GMP and several mechanisms of regulation of c-di-GMP metabolism. The contribution of c-di-GMP to regulating biofilm formation and motility, processes that affect pathogenesis of many bacteria, is described, as is c-di-GMP regulation of virulence gene expression. Finally, ways in which c-di-GMP may mediate these regulatory effects are proposed.|Bacteria/*pathogenicity[MESH]|Biofilms[MESH]|Cyclic GMP/*analogs & derivatives/chemistry/physiology[MESH]|Gene Expression Regulation, Bacterial[MESH]|Hydrolysis[MESH]|Movement[MESH]|Protein Structure, Tertiary[MESH]|Virulence/genetics[MESH] |
