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Regulation of transient receptor potential (TRP) channels by phosphoinositides Rohacs T; Nilius BPflugers Arch 2007[Oct]; 455 (1): 157-68This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP(2)) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP(2) and discusses some future challenges of this fascinating topic.|Animals[MESH]|Humans[MESH]|Phosphatidylinositol 4,5-Diphosphate/pharmacology[MESH]|Phosphatidylinositols/*pharmacology[MESH]|Transient Receptor Potential Channels/*drug effects[MESH] |
