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lüll How to evaluate the risk/benefit of trimodality therapy in locally advanced non-small-cell lung cancer Kunitoh H; Suzuki KBr J Cancer 2007[May]; 96 (10): 1498-503The trimodality approach represented by concurrent chemoradiotherapy followed by surgical resection is a highly effective, but potentially toxic therapy for locally advanced non-small-cell lung cancer (NSCLC). In this review, we discuss the current status of this therapy in patients with mediastinal node-positive (N2) stage III NSCLC or superior sulcus tumor, and present an overview of the principles for optimisation of the risk/benefit. Numerous clinical questions remain, and enrolment of patients into well-designed clinical trials should be encouraged.|*Combined Modality Therapy/adverse effects[MESH]|*Evaluation Studies as Topic[MESH]|Algorithms[MESH]|Antineoplastic Combined Chemotherapy Protocols/adverse effects/therapeutic use[MESH]|Carcinoma, Non-Small-Cell Lung/classification/pathology/*therapy[MESH]|Disease Progression[MESH]|Humans[MESH]|Lung Neoplasms/classification/pathology/*therapy[MESH]|Pulmonary Surgical Procedures/adverse effects[MESH]|Radiotherapy, Adjuvant/adverse effects[MESH]|Risk Assessment[MESH] |