Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The inflammasome in pathogen recognition and inflammation Sutterwala FS; Ogura Y; Flavell RAJ Leukoc Biol 2007[Aug]; 82 (2): 259-64The nucleotide-binding oligomerization domain-like receptor (NLR) family of proteins is involved in the regulation of innate immune responses and cell death pathways. Some NLR family members promote the activation of proinflammatory caspases within multiprotein complexes, called inflammasomes. Recent studies analyzing mice deficient in various components of the inflammasome have provided insight into the role of these molecules in host defense against pathogens and in autoinflammatory disorders. Here, we review these studies and propose that membrane disruption leads to activation of the inflammasome.|Animals[MESH]|Apoptosis Regulatory Proteins/immunology/metabolism[MESH]|CARD Signaling Adaptor Proteins/chemistry/*physiology[MESH]|Calcium-Binding Proteins/immunology/metabolism[MESH]|Carrier Proteins/immunology/metabolism[MESH]|Caspase 1/immunology/metabolism[MESH]|Enzyme Activation[MESH]|Humans[MESH]|Immunity, Innate/immunology[MESH]|Inflammation/*immunology/metabolism[MESH]|Mice[MESH]|Models, Immunological[MESH]|NLR Family, Pyrin Domain-Containing 3 Protein[MESH]|Protein Structure, Tertiary[MESH]|Receptors, Pattern Recognition/*physiology[MESH] |