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Manganese: recent advances in understanding its transport and neurotoxicity Aschner M; Guilarte TR; Schneider JS; Zheng WToxicol Appl Pharmacol 2007[Jun]; 221 (2): 131-47The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport of manganese (Mn) into the central nervous system (CNS), as well as brain imaging and neurocognitive studies in non-human primates aimed at improving our understanding of the mechanisms of Mn neurotoxicity. Finally, we discuss potential therapeutic modalities for treating Mn intoxication in humans.|Animals[MESH]|Behavior, Animal/drug effects[MESH]|Biological Transport[MESH]|Brain/diagnostic imaging/drug effects[MESH]|Manganese/*pharmacokinetics/*toxicity[MESH]|Positron-Emission Tomography[MESH]|Primates[MESH] |
