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lüll Hepatitis A vaccine associated with autoimmune hepatitis Berry PA; Smith-Laing GWorld J Gastroenterol 2007[Apr]; 13 (15): 2238-9To describe a case of probable relapsing autoimmune hepatitis associated with vaccination against hepatitis A virus (HAV). A case report and review of literature were written concerning autoimmune hepatitis in association with hepatitis A and other hepatotropic viruses. Soon after the administration of formalin-inactivated hepatitis A vaccine, a man who had recently recovered from an uncharacterized but self-limiting hepatitic illness, experienced a severe deterioration (AST 1687 U/L, INR 1.4). Anti-nuclear antibodies were detectable, and liver biopsy was compatible with autoimmune hepatitis. The observation supports the role of HAV as a trigger of autoimmune hepatitis. Studies in helper T-cell activity and antibody expression against hepatic proteins in the context of hepatitis A infection are summarized, and the concept of molecular mimicry with regard to other forms of viral hepatitis and autoimmunity is briefly explored.|Biopsy[MESH]|Hepatitis A Vaccines/*adverse effects[MESH]|Hepatitis A virus/physiology[MESH]|Hepatitis, Autoimmune/*diagnosis/*etiology[MESH]|Humans[MESH]|Liver/immunology/pathology/virology[MESH]|Male[MESH]|Middle Aged[MESH] |