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lüll The final touches make perfect the peptide-MHC class I repertoire Hammer GE; Kanaseki T; Shastri NImmunity 2007[Apr]; 26 (4): 397-406Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.|Animals[MESH]|Cytoplasm/immunology[MESH]|Endoplasmic Reticulum/*enzymology/immunology[MESH]|Histocompatibility Antigens Class I/*metabolism[MESH]|Humans[MESH]|Leucyl Aminopeptidase/deficiency/genetics/*metabolism[MESH]|Membrane Transport Proteins/metabolism[MESH]|Oxidation-Reduction[MESH]|Peptides/*immunology/*metabolism[MESH]|Protein Disulfide-Isomerases/*metabolism[MESH] |