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lüll piRNAs in the germ line Lin HScience 2007[Apr]; 316 (5823): 397Small noncoding RNAs have emerged as potent regulators of gene expression at both transcriptional and posttranscriptional levels. Recently, a class of small RNAs that interact with Piwi proteins has been discovered in the mammalian germ line and Drosophila. These Piwi-interacting RNAs (piRNAs) represent a distinct small RNA pathway.|Animals[MESH]|Argonaute Proteins[MESH]|Drosophila[MESH]|Drosophila Proteins/metabolism[MESH]|Epigenesis, Genetic[MESH]|Gene Expression Regulation, Developmental[MESH]|Germ Cells/cytology/*metabolism[MESH]|Mice[MESH]|Peptide Initiation Factors/metabolism[MESH]|Protein Biosynthesis[MESH]|Proteins/*metabolism[MESH]|RNA Stability[MESH]|RNA, Untranslated/genetics/*metabolism[MESH]|RNA-Induced Silencing Complex[MESH] |