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lüll Infliximab for the treatment of ulcerative colitis: outcomes in Oxford from 2000 to 2006 Jakobovits SL; Jewell DP; Travis SPAliment Pharmacol Ther 2007[May]; 25 (9): 1055-60BACKGROUND: Infliximab has been shown to be of benefit in the treatment of ulcerative colitis but long-term colectomy rates remain unknown. AIMS: To review the rate of colectomy after infliximab for ulcerative colitis and to identify factors that might predict the need for colectomy. METHODS: We conducted a retrospective cohort study of patients with active ulcerative colitis treated with infliximab between 2000 and 2006. The primary outcome was colectomy-free survival. Disease and treatment characteristics and complications were documented. RESULTS: Thirty patients were treated with infliximab for refractory ulcerative colitis. Sixteen (53%) came to colectomy a median of 140 days after their first infusion (range 4-607). There was no difference in colectomy between those receiving infliximab for acute severe ulcerative colitis failing intravenous steroids (8/14) and out-patients with steroid-refractory ulcerative colitis (8/16). Only 17% (5/30) achieved a steroid-free remission after a median follow-up of 13 months (range 2-72). Univariate analysis showed that a younger age at diagnosis of colitis was significantly associated with an increased rate of colectomy (27.5 years vs. 38.7 years, P = 0.016). CONCLUSION: Over half the patients studied came to colectomy. Of those avoiding colectomy, only five (17%) sustained a steroid-free remission.|Antibodies, Monoclonal/*therapeutic use[MESH]|Cohort Studies[MESH]|Colectomy/*statistics & numerical data[MESH]|Colitis, Ulcerative/*drug therapy/surgery[MESH]|Disease-Free Survival[MESH]|Female[MESH]|Gastrointestinal Agents/*therapeutic use[MESH]|Humans[MESH]|Infliximab[MESH]|Male[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]|Treatment Outcome[MESH] |