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Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas van der Hoek J; Lamberts SWJ; Hofland LJEur J Endocrinol 2007[Apr]; 156 Suppl 1 (ä): S45-S51The patho-physiological role of somatostatin receptor subtypes (sst) in neuro endocrine diseases has gained enhanced scientific interest in the past few years. The development of novel somatotropin-release inhibiting factor analogs, both sst-specific and universal ligands, seem promising as a tool to further increase fundamental insights in sst function. Eventually, this research should result in novel medical therapeutic opportunities in patients suffering from neuro-endocrine diseases. In the present review, the functional role of sst in all types of pituitary adenomas, based on recent preclinical and clinical studies, is being discussed.|Adenoma/*drug therapy/metabolism[MESH]|Humans[MESH]|Pituitary Neoplasms/*drug therapy/metabolism[MESH]|Receptors, G-Protein-Coupled/drug effects/physiology[MESH]|Receptors, Somatostatin/*drug effects/physiology[MESH]|Somatostatin/*analogs & derivatives[MESH] |
