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Post-transcriptional control of the interferon system Khabar KS; Young HABiochimie 2007[Jun]; 89 (6-7): 761-9The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response.|*RNA Processing, Post-Transcriptional[MESH]|3' Untranslated Regions[MESH]|Animals[MESH]|Base Sequence[MESH]|Endoribonucleases/metabolism[MESH]|Feedback, Physiological[MESH]|Humans[MESH]|Interferon-beta/metabolism[MESH]|Interferon-gamma/metabolism[MESH]|Interferons/biosynthesis/chemistry/*metabolism[MESH]|Models, Biological[MESH]|Molecular Sequence Data[MESH]|Signal Transduction[MESH]|Transcription, Genetic[MESH]|eIF-2 Kinase/metabolism[MESH] |
