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lüll GI epidemiology: nonalcoholic fatty liver disease Angulo PAliment Pharmacol Ther 2007[Apr]; 25 (8): 883-9BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a common diagnosis in clinical practice. Insulin resistance and oxidative stress play an important role in NAFLD development and progression. AIM: To review the data available on the epidemiology and natural history of NAFLD as well as the risk factors for its development and the areas where future research is necessary. RESULTS /CONCLUSIONS: NAFLD may affect individuals of any age range and race/ethnicity. NAFLD affects one in three adults and one in ten children/adolescents in the United States. Mortality in patients with NAFLD is significantly higher than in the general population of same age and gender with liver-related complications being a common cause of death. Liver-related morbidity and mortality in NAFLD occurs when the disease has progressed to advanced fibrosis and cirrhosis. Further studies are necessary to determine the impact of NAFLD on health-related quality of life and resources utilization, and to the extent to which preventing the development of the metabolic syndrome would prevent NAFLD development and reduce liver-related morbidity and mortality. Lifestyle intervention may improve NAFLD, but medications that increase insulin sensitivity and the antioxidant defenses in the liver deserve evaluation in carefully controlled trials.|Disease Progression[MESH]|Fatty Liver/epidemiology/ethnology/*etiology[MESH]|Female[MESH]|Global Health[MESH]|Humans[MESH]|Male[MESH]|Obesity/*complications/epidemiology/metabolism[MESH]|Prevalence[MESH]|Risk Factors[MESH] |