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lüll Triggering the innate antiviral response through IRF-3 activation Hiscott JJ Biol Chem 2007[May]; 282 (21): 15325-9Rapid induction of type I interferon (IFN) expression is a central event in the establishment of the innate immune response against viral infection and requires the activation of multiple transcriptional proteins following engagement and signaling through Toll-like receptor-dependent and -independent pathways. The transcription factor interferon regulatory factor-3 (IRF-3) contributes to a first line of defense against viral infection by inducing the production of IFN-beta that in turn amplifies the IFN response and the development of antiviral activity. In murine knock-out models, the absence of IRF-3 and the closely related IRF-7 ablates IFN production and increases viral pathogenesis, thus supporting a pivotal role for IRF-3/IRF-7 in the development of the host antiviral response.|Animals[MESH]|Humans[MESH]|Immunity, Innate/*physiology[MESH]|Interferon Regulatory Factor-3/*immunology[MESH]|Interferon Regulatory Factor-7/immunology[MESH]|Interferon Type I/*immunology[MESH]|Signal Transduction/*immunology[MESH]|Virus Diseases/*immunology[MESH]|Viruses/*immunology[MESH] |