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Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents Altmann KH; Gertsch JNat Prod Rep 2007[Apr]; 24 (2): 327-57This review article provides an overview on the current state of research in the area of microtubule-stabilizing agents from natural sources, with a primary focus on the biochemistry, biology, and pharmacology associated with these compounds. A variety of natural products have been discovered over the last decade to inhibit human cancer cell proliferation through a taxol-like mechanism. These compounds represent a whole new range of structurally diverse lead structures for anticancer drug discovery.|*Antineoplastic Agents, Phytogenic/chemistry/isolation & purification/pharmacology[MESH]|*Biological Products/chemistry/isolation & purification/pharmacology[MESH]|Humans[MESH]|Microtubules/*drug effects[MESH]|Molecular Structure[MESH]|Paclitaxel/chemistry/isolation & purification/pharmacology[MESH] |
