Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17384421&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Functional analysis of the role of POK transcriptional repressors Costoya JABrief Funct Genomic Proteomic 2007[Mar]; 6 (1): 8-18Transcription factors (TF) play a key role in certain mechanisms by which specific genes are expressed in a temporal and tissue-specific manner. Understanding those mechanisms is still a challenging question in biology. Their modular organization allows the possibility of classifying them based on the structure of the domains that bind DNA or interact with other proteins. Those domains not only define the different TF families but also provide insights into the biological functions played by them. Among these, the POK (Poxviruses and Zinc-finger (POZ) and Kruppel) family of transcription repressors is characterized by the presence in their structures of an amino-terminal POZ/Broad Complex, Tramtrack, and Bric a brac (BTB) domain and several Kruppel-type zinc fingers at the carboxy-terminal moiety. The POZ/BTB domain mediates homo- and heterodimerization as well as protein-protein interactions, allowing the recruitment of corepressor complexes. On the other hand, the specific zinc fingers mediate specific DNA sequences recognition and binding. In the last few years, several reports have highlighted the importance that this family of transcriptional repressors plays in different processes such as cancer, development and stem cell biology.|Animals[MESH]|Cell Cycle/genetics[MESH]|Cell Differentiation/genetics[MESH]|DNA-Binding Proteins/genetics/physiology[MESH]|Disease Progression[MESH]|Gene Expression Regulation, Developmental[MESH]|Genes, Homeobox[MESH]|Growth and Development/genetics[MESH]|Humans[MESH]|Kruppel-Like Transcription Factors/genetics/*physiology[MESH]|Mice[MESH]|Models, Biological[MESH]|Neoplasms/genetics/pathology[MESH]|Promyelocytic Leukemia Zinc Finger Protein[MESH]|Proto-Oncogene Proteins c-bcl-6[MESH]|Repressor Proteins/*physiology[MESH]|Stem Cells/cytology[MESH]|T-Lymphocytes/cytology/metabolism[MESH]|Transcription Factors/physiology[MESH] |
