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Cyclin-dependent kinases: molecular switches controlling anergy and potential therapeutic targets for tolerance Wells ADSemin Immunol 2007[Jun]; 19 (3): 173-9A large body of research has established the importance of costimulatory signals and proliferation for the generation of productive T cell immune responses. While costimulation and cell cycle progression are each individually necessary for CD4+ effector T cell differentiation, it has become clear that neither of these processes alone is sufficient to avoid anergy. This review outlines the links between T cell differentiation, tolerance, and the cell cycle, and highlights recent work that has implicated cyclin-dependent kinases as important regulators and potential targets for modulation of T cell immunity and tolerance.|*Immunotherapy[MESH]|Animals[MESH]|Cell Cycle[MESH]|Cyclin-Dependent Kinase Inhibitor Proteins/physiology[MESH]|Cyclin-Dependent Kinases/*physiology[MESH]|Humans[MESH]|Immune Tolerance/*immunology[MESH]|T-Lymphocytes/cytology/*immunology[MESH] |
