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lüll A dynamic machinery for import of mitochondrial precursor proteins Bohnert M; Pfanner N; van der Laan MFEBS Lett 2007[Jun]; 581 (15): 2802-10Mitochondria contain approximately 1000 different proteins, which are located in four different compartments, outer membrane, inner membrane, intermembrane space and matrix. The vast majority of these proteins has to be imported from the cytosol. Therefore, sophisticated molecular machineries have evolved that mediate protein translocation across or insertion into mitochondrial membranes and subsequent assembly into multi-subunit complexes. While the initial entry of virtually all mitochondrial proteins is mediated by the general import pore of the outer membrane, at least four different downstream pathways are dedicated to import and assembly of proteins into a specific compartment.|Adenosine Triphosphate/metabolism[MESH]|Biological Transport, Active[MESH]|Carrier Proteins/chemistry/metabolism[MESH]|Mitochondrial Membrane Transport Proteins/chemistry/metabolism[MESH]|Mitochondrial Membranes/chemistry/metabolism[MESH]|Mitochondrial Precursor Protein Import Complex Proteins[MESH]|Mitochondrial Proteins/chemistry/*metabolism[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Molecular Motor Proteins/chemistry/metabolism[MESH]|Multiprotein Complexes[MESH]|Protein Precursors/chemistry/*metabolism[MESH] |