Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?Boutet A; Esteban MA; Maxwell PH; Nieto MACell Cycle 2007[Mar]; 6 (6): 638-42While the activity of Snail genes is required during embryonic development for the formation of different tissues and organs, they must be repressed in the adult in order to maintain epithelial integrity and homeostasis. Indeed, pathological activation of Snail in epithelial tumors induces malignancy and the recurrence of tumors. Here we show that in dedifferentiated areas of human renal carcinomas, Snail undergoes a process of reactivation. In addition to tumor progression, renal fibrosis is also linked to the activity of Snail genes and indeed, reactivation of Snail in the adult kidney is sufficient to induce fibrosis. Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases.|*Gene Expression Regulation, Neoplastic/physiology[MESH]|Animals[MESH]|Carcinoma/*embryology/genetics/pathology[MESH]|Embryonic Development/*genetics[MESH]|Fibrosis[MESH]|Humans[MESH]|Kidney Neoplasms/*embryology/genetics/pathology[MESH]|Kidney/*embryology/metabolism/*pathology[MESH]|Snail Family Transcription Factors[MESH]|Transcription Factors/*genetics/*metabolism[MESH] |