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Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs Hawkey CJ; Jones RH; Yeomans ND; Scheiman JM; Talley NJ; Goldstein JL; Ahlbom H; Naesdal JAliment Pharmacol Ther 2007[Apr]; 25 (7): 813-21BACKGROUND: The use of non-steroidal anti-inflammatory drugs (NSAIDs) is often associated with upper gastrointestinal symptoms such as heartburn and acid regurgitation. AIM: To assess the efficacy of esomeprazole 20 and 40 mg for resolution of heartburn and acid regurgitation in continuous NSAIDs. METHODS: A post hoc analysis of five clinical trials was performed. Two identically designed, placebo-controlled, 4-week studies (NASA1, SPACE1) enrolled non-ulcer, NSAIDs-treated patients with upper abdominal pain, discomfort or burning. PLUTO and VENUS were identically designed, placebo-controlled, 6-month studies that enrolled patients at risk of NSAIDs-induced ulcers. Study 285 was an 8-week comparative study with ranitidine (300 mg/day) in patients with NSAIDs-induced gastric ulcers. Resolution of investigator-assessed heartburn and acid regurgitation was defined as symptom severity of 'none' in the last 7 days. RESULTS: In NASA1/SPACE1, heartburn resolved in 61% and 62% of patients taking esomeprazole 20 and 40 mg, respectively (vs. 36% on placebo, P < 0.001), and acid regurgitation resolved in 65% and 67% (vs. 48%, P < 0.001). Resolution of both symptoms was greater with esomeprazole than with placebo in PLUTO/VENUS (P |Adult[MESH]|Anti-Inflammatory Agents, Non-Steroidal/*adverse effects[MESH]|Anti-Ulcer Agents/*therapeutic use[MESH]|Esomeprazole/*therapeutic use[MESH]|Female[MESH]|Gastroesophageal Reflux/chemically induced/*prevention & control[MESH]|Heartburn/chemically induced/*prevention & control[MESH]|Humans[MESH]|Middle Aged[MESH]|Multicenter Studies as Topic[MESH]|Randomized Controlled Trials as Topic[MESH]|Treatment Outcome[MESH] |
