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lüll The biology of metastasis to a sanctuary site Palmieri D; Chambers AF; Felding-Habermann B; Huang S; Steeg PSClin Cancer Res 2007[Mar]; 13 (6): 1656-62Metastasis to the brain is prevalent in solid tumors and lymphomas, and is associated with shortened survival. The brain is regarded as a sanctuary site for metastatic tumor cells where they exist partially protected from drugs by the blood-tumor barrier. Model systems for brain metastasis have been developed and are now yielding mechanistic insights into the roles of angiogenesis, energy metabolism, the Her-2 and Stat3 signaling pathways, and dormancy. Specific, new approaches to combat brain metastatic disease are needed.|Animals[MESH]|Brain Neoplasms/blood supply/*etiology/*secondary[MESH]|Brain/blood supply[MESH]|Cell Membrane Permeability/physiology[MESH]|Disease Models, Animal[MESH]|Disease Progression[MESH]|Energy Metabolism/physiology[MESH]|Humans[MESH]|Melanoma, Experimental/pathology[MESH]|Models, Biological[MESH]|Neovascularization, Pathologic/pathology[MESH]|Receptor, ErbB-2/physiology[MESH]|STAT3 Transcription Factor/physiology[MESH] |