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lüll Dalbavancin: a novel antimicrobial Chen AY; Zervos MJ; Vazquez JAInt J Clin Pract 2007[May]; 61 (5): 853-63The increasing incidence of serious infections because of Gram-positive pathogens and the rising cost in parenteral administration of antimicrobials has inspired the development of a novel antibiotic. Dalbavancin is the first once a week antibiotic with activity against a broad range of Gram-positive pathogens. A large multicentre, pivotal, Phase III clinical trial, which included 854 patients with complicated skin and skin structure infections, compared 1-2 doses of dalbavancin vs. linezolid. The results demonstrated non-inferiority and a comparable safety profile. With its unique pharmacokinetic profile, ease of use and excellent safety profile, dalbavancin should provide a valuable addition to the armamentarium used to treat infections because of Gram-positive cocci.|Anti-Bacterial Agents/pharmacology/*therapeutic use[MESH]|Drug Interactions[MESH]|Humans[MESH]|Research Design[MESH]|Teicoplanin/*analogs & derivatives/pharmacology/therapeutic use[MESH]|Treatment Outcome[MESH] |