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Evolution and multilevel optimization of the genetic code Bollenbach T; Vetsigian K; Kishony RGenome Res 2007[Apr]; 17 (4): 401-4The discovery of the genetic code was one of the most important advances of modern biology. But there is more to a DNA code than protein sequence; DNA carries signals for splicing, localization, folding, and regulation that are often embedded within the protein-coding sequence. In this issue, Itzkovitz and Alon show that the specific 64-to-20 mapping found in the genetic code may have been optimized for permitting protein-coding regions to carry this extra information and suggest that this property may have evolved as a side benefit of selection to minimize the negative effects of frameshift errors.|*Evolution, Molecular[MESH]|Amino Acids/genetics[MESH]|Codon, Terminator/genetics[MESH]|Codon/genetics[MESH]|Genetic Code/*genetics[MESH]|Open Reading Frames/*genetics[MESH]|Protein Biosynthesis[MESH] |
