Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=17339568&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Predictors of mortality in chronic Chagas disease: a systematic review of observational studies Rassi A Jr; Rassi A; Rassi SGCirculation 2007[Mar]; 115 (9): 1101-8BACKGROUND: Chagas disease is a major cause of morbidity and mortality in Latin America. Knowledge of the predictors of prognosis can help clinical decision making by identifying patients' level of risk. METHODS AND RESULTS: We reviewed the published literature on prognostic factors in patients with Chagas disease by performing a PubMed search for articles published in any language between 1985 and February 2006 and hand searches of the reference lists of retrieved articles. Studies were selected if they included patients in the chronic phase of Chagas disease, analyzed a clearly defined outcome (all-cause mortality, sudden cardiac deaths, and/or cardiovascular deaths), and used multivariable regression models of prognosis. From 606 potentially relevant studies, 12 met the inclusion criteria: 8 clinic-based studies including 3928 patients and 4 hospital-based studies including 349 patients. Impaired left ventricular function by echocardiogram or cineventriculogram was found to be the most common and consistent independent predictor of death. New York Heart Association functional class III/IV and cardiomegaly on the chest radiography also were independently associated with higher mortality. More recently, strong evidence was found that nonsustained ventricular tachycardia on 24-hour Holter monitoring indicated an adverse prognosis. The typical ECG abnormalities showed limited additional prognostic value. Other often-mentioned risk factors, advanced age and male sex, showed inconsistent results. A formal meta-analysis was not feasible because of the heterogeneity of published studies and the lack of minimal standards in reporting results. CONCLUSIONS: A systematic review of published studies indicates that impaired left ventricular function, New York Heart Association class III/IV, cardiomegaly, and nonsustained ventricular tachycardia indicate a poor prognosis in patients with chronic Chagas disease.|Adult[MESH]|Aged[MESH]|Algorithms[MESH]|Cardiomegaly/epidemiology/etiology[MESH]|Case Management[MESH]|Chagas Cardiomyopathy/complications/mortality[MESH]|Chagas Disease/*mortality[MESH]|Chronic Disease[MESH]|Death, Sudden, Cardiac/epidemiology[MESH]|Electrocardiography[MESH]|Electrocardiography, Ambulatory[MESH]|Female[MESH]|Follow-Up Studies[MESH]|Heart Failure/epidemiology/etiology[MESH]|Humans[MESH]|Kaplan-Meier Estimate[MESH]|Latin America/epidemiology[MESH]|Male[MESH]|Middle Aged[MESH]|Multivariate Analysis[MESH]|Prognosis[MESH]|Radiography[MESH]|Risk[MESH]|Tachycardia, Ventricular/epidemiology/etiology[MESH]|Ultrasonography[MESH]|Ventricular Dysfunction, Left/diagnostic imaging/epidemiology/etiology[MESH] |
