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lüll Burden of recurrent Chlamydia trachomatis infections in young women: further uncovering the "hidden epidemic" Niccolai LM; Hochberg AL; Ethier KA; Lewis JB; Ickovics JRArch Pediatr Adolesc Med 2007[Mar]; 161 (3): 246-51OBJECTIVE: To determine the frequency and patterns of recurrent Chlamydia trachomatis infections, the most common bacterial sexually transmitted infection in young women. DESIGN: Cohort study using different data collection methods, including face-to-face interviews, medical record reviews, urine-based screening for C trachomatis infections, and a review of state health department reports of C trachomatis diagnoses. SETTING: Ten community-based health centers that provided reproductive health care from June 1998 to September 2001. PARTICIPANTS: Eligibility criteria included being nulliparous, between the ages of 14 and 19 years, and human immunodeficiency virus-negative, all at the time of recruitment. This convenience sample (N = 411) was recruited by word of mouth, clinician referrals, and advertisements in the clinics. Prospective follow-up data were available for 93.9% (386/411) of the sample. The exposure of interest was prior chlamydia infection. Main Outcome Measure Diagnosis of recurrent C trachomatis infection. RESULTS: During the follow-up period of 23 318 person-months (mean, 4.7 years per person), 216 participants (52.6%) were diagnosed as having C trachomatis infection, and 123 participants (29.9% of the total sample and 56.9% of those with initial infections) were diagnosed as having recurrent C trachomatis infections. Of 456 C trachomatis diagnoses made during the study period, 241 (52.9%) were recurrent infections. The rate of recurrent infections was 42.1 per 1000 person-months. The median time to recurrent infection was 5.2 months. CONCLUSION: Recurrent C trachomatis infections comprise a substantial health burden among young women, possibly higher than previously recognized in this vulnerable population.|*Chlamydia trachomatis[MESH]|Adolescent[MESH]|Adult[MESH]|Chlamydia Infections/*epidemiology[MESH]|Cohort Studies[MESH]|Female[MESH]|Humans[MESH]|Recurrence[MESH] |