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Signal transduction induced in endothelial cells by growth factor receptors involved in angiogenesis Hofer E; Schweighofer BThromb Haemost 2007[Mar]; 97 (3): 355-63New vessel formation during development and in the adult is triggered by concerted signals of largely endothelial-specific receptors for ligands of the VEGF, angiopoietin and ephrin families. The signals and genes induced by these receptors operate in the context of additional signals transduced by non-endothelial specific growth factor receptors, inflammatory cytokine receptors as well as adhesion molecules. We summarize here available data on characteristic signaling of the VEGF receptor-2 and the current state of knowledge regarding the additional different receptor tyrosine kinases of the VEGF, Tie and Ephrin receptor families. Furthermore, the potential cross-talk with signals induced by other growth factors and inflammatory cytokines as well as the modulation by VE-cadherin is discussed.|*Neovascularization, Physiologic[MESH]|*Signal Transduction[MESH]|Angiopoietins/metabolism[MESH]|Animals[MESH]|Antigens, CD/metabolism[MESH]|Cadherins/metabolism[MESH]|Cytokines/metabolism[MESH]|Endothelial Cells/*metabolism[MESH]|Ephrins/metabolism[MESH]|Humans[MESH]|Receptor Cross-Talk[MESH]|Receptors, Eph Family/metabolism[MESH]|Receptors, Growth Factor/*metabolism[MESH]|Receptors, TIE/metabolism[MESH]|Vascular Endothelial Growth Factor Receptor-2/metabolism[MESH]|Vascular Endothelial Growth Factors/metabolism[MESH] |
