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lüll Beyond the sequence: cellular organization of genome function Misteli TCell 2007[Feb]; 128 (4): 787-800Genomes are more than linear sequences. In vivo they exist as elaborate physical structures, and their functional properties are strongly determined by their cellular organization. I discuss here the functional relevance of spatial and temporal genome organization at three hierarchical levels: the organization of nuclear processes, the higher-order organization of the chromatin fiber, and the spatial arrangement of genomes within the cell nucleus. Recent insights into the cell biology of genomes have overturned long-held dogmas and have led to new models for many essential cellular processes, including gene expression and genome stability.|Animals[MESH]|Cell Compartmentation[MESH]|Cell Nucleus/*genetics[MESH]|Chromatin/*genetics[MESH]|Epigenesis, Genetic/genetics[MESH]|Gene Expression Regulation/*genetics[MESH]|Genome/*genetics[MESH]|Genomic Instability/*genetics[MESH]|Humans[MESH]|Stochastic Processes[MESH] |