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lüll Cells of the synovium in rheumatoid arthritis T lymphocytes Lundy SK; Sarkar S; Tesmer LA; Fox DAArthritis Res Ther 2007[]; 9 (1): 202Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here, we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal models and in patients with RA is also discussed. In light of the overwhelming evidence that disrupted T-cell homeostasis greatly contributes to joint pathology in RA, the therapeutic potential of targeting activators of pro-inflammatory T cells or their products is compelling.|Animals[MESH]|Arthritis, Rheumatoid/immunology/*pathology[MESH]|Humans[MESH]|Synovial Membrane/immunology/*pathology[MESH]|T-Lymphocyte Subsets/immunology/*pathology[MESH] |