Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Hypoxia-induced and stress-specific changes in chromatin structure and function Johnson AB; Barton MCMutat Res 2007[May]; 618 (1-2): 149-62Cellular adaptation to stress relies on specific, regulated responses to evoke changes in gene expression. Stresses such as hypoxia, heat shock, oxidative stress and DNA-damage activate signaling cascades that ultimately lead to either induction or repression of stress-responsive genes. In this review, we concentrate on the mechanisms by which stress-induced signaling promotes alterations in chromatin structure, whether the read-out is activation or repression of transcription. Specific alterations in chromatin are highly regulated and dictated by the type of imposed stress. Our primary focus is on the types of chromatin alterations that occur under hypoxic conditions, which exist within a majority of tumors, and to compare these to changes in chromatin structure that occur in response to a wide variety of cellular stresses.|*Chromatin Assembly and Disassembly[MESH]|*Gene Expression Regulation[MESH]|*Hypoxia[MESH]|Animals[MESH]|Chromatin/*chemistry[MESH]|DNA Damage[MESH]|Heat-Shock Response[MESH]|Histone Acetyltransferases/metabolism[MESH]|Histones/chemistry[MESH]|Humans[MESH]|Oxidative Stress[MESH]|Phosphorylation[MESH]|Protein Binding[MESH]|Transcription, Genetic[MESH] |