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lüll Ratcheting mRNA out of the nucleus Stewart MMol Cell 2007[Feb]; 25 (3): 327-30Export of mature mRNA to the cytoplasm is the culmination of the nuclear portion of eukaryotic gene expression. After transport-competent mature mRNP export complexes are formed in the nucleus, their passage through nuclear pore complexes (NPCs) is facilitated by the Mex67:Mtr2 heterodimer. At the NPC cytoplasmic face, mRNP remodeling prevents its return to the nucleus and so functions as a molecular ratchet imposing directionality on transport. In budding yeast, recent work suggests that the DEAD-box helicase Dbp5 remodels mRNPs at the NPC cytoplasmic face by removing Mex67 and that the Dbp5 ATPase is activated by Gle1 and inositol hexaphosphate (IP(6)).|*Models, Biological[MESH]|Active Transport, Cell Nucleus/physiology[MESH]|Carrier Proteins/physiology[MESH]|Cell Nucleus/*metabolism[MESH]|DEAD-box RNA Helicases/physiology[MESH]|Dimerization[MESH]|Membrane Transport Proteins/metabolism[MESH]|Nuclear Pore Complex Proteins/physiology[MESH]|Nuclear Proteins/metabolism[MESH]|Nucleocytoplasmic Transport Proteins/metabolism/physiology[MESH]|Phytic Acid/metabolism[MESH]|Protein Processing, Post-Translational[MESH]|RNA Helicases/physiology[MESH]|RNA, Messenger/*metabolism[MESH]|RNA-Binding Proteins/metabolism[MESH]|Ribonucleoproteins/metabolism[MESH]|Saccharomyces cerevisiae Proteins/metabolism/physiology[MESH] |