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Chemistry and biology of resorcylic acid lactones Winssinger N; Barluenga SChem Commun (Camb) 2007[Jan]; ä (1): 22-36While resorcylic acid lactones (RALs) have been known for a long time, the more recent discoveries that radicicol is a potent and selective HSP90 inhibitor while other members such as hypothemycin, LL-Z1640-2 and LL-783,277 are potent kinase inhibitors have stimulated a renewed interest in this family of natural products. The recent developments regarding the chemistry and biology of RALs are reviewed.|HSP90 Heat-Shock Proteins/antagonists & inhibitors[MESH]|Hydroxybenzoates/*chemistry[MESH]|Lactones/*chemical synthesis/chemistry/pharmacology[MESH]|Macrocyclic Compounds/chemical synthesis/chemistry/pharmacology[MESH]|Macrolides/chemical synthesis/chemistry/pharmacology[MESH]|Mitogen-Activated Protein Kinases/antagonists & inhibitors[MESH]|Molecular Structure[MESH]|Mycotoxins/*chemical synthesis/chemistry/pharmacology[MESH]|Zearalenone/analogs & derivatives/chemical synthesis/chemistry/pharmacology[MESH] |
