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Management of patients with HBeAg-negative chronic hepatitis B Saikia N; Talukdar R; Mazumder S; Khanna S; Tandon RPostgrad Med J 2007[Jan]; 83 (975): 32-9Chronic hepatitis B (CHB) is one of the leading causes of morbidity and mortality worldwide. Although various drugs are available for the treatment of CHB, emergence of the hepatitis B e antigen (HBeAg)-negative mutant variant, specifically in Asia, the Middle East and southern Europe, is creating a new challenge as this variant is less responsive to available treatments. HBeAg-negative CHB rapidly progresses to cirrhosis and its related complications. This review discusses the available literature on the approved and under-trial treatment options and their respective efficacies for HBeAg-negative CHB.|Antiviral Agents/*therapeutic use[MESH]|Forecasting[MESH]|Hepatitis B e Antigens/blood[MESH]|Hepatitis B, Chronic/blood/*drug therapy[MESH]|Humans[MESH] |
