Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma Ochoa AC; Zea AH; Hernandez C; Rodriguez PCClin Cancer Res 2007[Jan]; 13 (2 Pt 2): 721s-726sTumor-induced tolerance is a well-established phenomenon in cancer patients that can severely impair the therapeutic efficacy of immunotherapy. One mechanism leading to T-cell tolerance is the generation of myeloid-derived suppressor cells (MDSC) by soluble factors produced by the tumor. MDSC express CD11b(+) as a common marker but may vary in their stage of maturation, depending on the tumor factors being produced. Arginase production by MDSC depletes arginine from the tumor microenvironment and impairs T-cell signal transduction and function. We studied whether an increase in MDSC could explain the molecular alterations and dysfunction found in T cells of patients with renal cell carcinoma (RCC). Arginase activity in the peripheral blood mononuclear cells of 117 RCC patients was increased between 6- to 8-fold compared with normal controls. The increased arginase activity was limited to the CD11b(+)CD14(-) myeloid cells and resulted in significantly decreased serum levels of arginine and increased ornithine in patients. Depletion of MDSC restored IFN-gamma production and T-cell proliferation. Preliminary data suggest that prostaglandin E(2) produced by the tumor induces arginase I expression in MDSC. Therefore, blocking MDSC activity may enhance the therapeutic efficacy of immunotherapy in RCC.|Animals[MESH]|Arginase/*biosynthesis/metabolism[MESH]|CD11b Antigen/biosynthesis[MESH]|Carcinoma, Renal Cell/*metabolism[MESH]|Cyclooxygenase 2/biosynthesis[MESH]|Dinoprostone/metabolism[MESH]|Disease Models, Animal[MESH]|Humans[MESH]|Interferon-gamma/biosynthesis[MESH]|Kidney Neoplasms/*metabolism[MESH]|Lipopolysaccharide Receptors/biosynthesis[MESH]|Mice[MESH]|Myeloid Cells/*metabolism[MESH]|Neoplasm Metastasis[MESH]|Prostaglandins/*metabolism[MESH]|T-Lymphocytes/metabolism[MESH] |