Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors Mellinghoff IK; Cloughesy TF; Mischel PSClin Cancer Res 2007[Jan]; 13 (2 Pt 1): 378-81Molecularly targeted therapies are transforming the treatment of cancer. Elucidating the dynamic signaling networks that underlie sensitivity and resistance to these inhibitors is critical for successful clinical application. There is considerable evidence to suggest that constitutively activating mutations in kinases that regulate cellular growth may result in tumor cell "addiction" and favorable response to targeted inhibition. However, there is emerging evidence to suggest that clinical response may also be determined by other changes in the molecular circuitry of cancer cells, such as loss of key tumor-suppressor proteins. Here, we will discuss resistance to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma patients that is mediated by loss of the PTEN tumor-suppressor protein.|Animals[MESH]|Brain Neoplasms/*metabolism[MESH]|Enzyme Inhibitors/*pharmacology[MESH]|ErbB Receptors/*antagonists & inhibitors/*physiology[MESH]|Glioblastoma/*metabolism[MESH]|Humans[MESH]|Models, Biological[MESH]|Neoplasms/metabolism[MESH]|PTEN Phosphohydrolase/*physiology[MESH]|Phosphatidylinositol 3-Kinases/metabolism[MESH]|Signal Transduction[MESH] |
