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Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy Singh AP; Chaturvedi P; Batra SKCancer Res 2007[Jan]; 67 (2): 433-6The MUC4 mucin is a transmembrane glycoprotein that is implicated in the pathogenesis of pancreatic cancer and is aberrantly expressed in many other epithelial carcinomas. Recent studies suggest its significant potential as a clinical tool for cancer diagnosis and prognosis. MUC4 modulates HER2/ErbB2 signaling and is a determinant of therapeutic outcome of Herceptin-based therapy, which further indicates its prospective usefulness in cancer therapy and treatment planning.|Animals[MESH]|Biomarkers, Tumor/metabolism[MESH]|Female[MESH]|Humans[MESH]|Mucin-4[MESH]|Mucins/*metabolism[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/diagnosis/*metabolism/pathology/therapy[MESH]|Ovarian Neoplasms/diagnosis/metabolism/pathology/therapy[MESH]|Pancreatic Neoplasms/diagnosis/metabolism/pathology/therapy[MESH] |
