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lüll Ciona intestinalis as a model for cardiac development Davidson BSemin Cell Dev Biol 2007[Feb]; 18 (1): 16-26The primitive chordate Ciona intestinalis has emerged as a significant model system for the study of heart development. The Ciona embryo employs a conserved heart gene network in the context of extremely low cell numbers and reduced genetic redundancy. Here, I review recent studies on the molecular genetics of Ciona cardiogenesis as well as classic work on heart anatomy and physiology. I also discuss the potential of employing Ciona to decipher a comprehensive chordate gene network and to determine how this network controls heart morphogenesis.|Animals[MESH]|Biological Evolution[MESH]|Cell Lineage[MESH]|Ciona intestinalis/anatomy & histology/*embryology/genetics/physiology[MESH]|Gene Expression Regulation, Developmental[MESH]|Gene Regulatory Networks/physiology[MESH]|Heart/anatomy & histology/*embryology/physiology[MESH]|Models, Animal[MESH]|Models, Biological[MESH]|Morphogenesis/genetics[MESH] |