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The prokineticins: a novel pair of regulatory peptides Zhou QYMol Interv 2006[Dec]; 6 (6): 330-8Secreted peptides play broad regulatory roles in brain function and elsewhere in the body. Prokineticins are a pair of newly identified regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and a completely conserved N-terminal hexapeptide sequence that is essential to biological activity. Diverse biological functions, including roles in development and cell differentiation, have been assigned to the prokineticins. A network of genes, subject to various transcriptional factors, may functionally converge on the prokineticins as regulatory targets.|Amino Acid Sequence[MESH]|Animals[MESH]|Circadian Rhythm/physiology[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Muscle Contraction[MESH]|Muscle, Smooth/physiology[MESH]|Peptides/chemistry/genetics/*metabolism[MESH]|Signal Transduction[MESH]|Vascular Endothelial Growth Factor, Endocrine-Gland-Derived/chemistry/genetics/*metabolism[MESH] |
