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lüll FT-IR imaging of native and tissue-engineered bone and cartilage Boskey A; Pleshko Camacho NBiomaterials 2007[May]; 28 (15): 2465-78Fourier transform infrared (FT-IR) imaging and microspectroscopy have been extensively applied to the analyses of tissues in health and disease. Spatially resolved mid-IR data has provided insights into molecular changes that occur in diseases of connective or collagen-based tissues, including, osteoporosis, osteogenesis imperfecta, osteopetrosis and pathologic calcifications. These techniques have also been used to probe chemical changes associated with load, disuse, and micro-damage in bone, and with degradation and repair in cartilage. This review summarizes the applications of FT-IR microscopy and imaging for analyses of bone and cartilage in healthy and diseased tissues, and illustrates the application of these techniques for the characterization of tissue-engineered bone and cartilage.|Animals[MESH]|Bone and Bones/anatomy & histology/*chemistry[MESH]|Cartilage/anatomy & histology/*chemistry[MESH]|Collagen/analysis[MESH]|Diagnostic Imaging/*methods[MESH]|Humans[MESH]|Proteoglycans/analysis[MESH]|Spectroscopy, Fourier Transform Infrared/*methods[MESH]|Tissue Engineering/methods[MESH] |