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lüll Re-employment of developmental transcription factors in adult heart disease Oka T; Xu J; Molkentin JDSemin Cell Dev Biol 2007[Feb]; 18 (1): 117-31A finite number of transcription factors constitute a combinatorial code that orchestrates cardiac development and the specification and differentiation of myocytes. Many, if not all of these same transcription factors are re-employed in the adult heart in response to disease stimuli that promote hypertrophic enlargement and/or dilated cardiomyopathy, as part of the so-called "fetal gene program". This review will discuss the transcription factors that regulate the hypertrophic growth response of the adult heart, with a special emphasis on those regulators that participate in cardiac development.|Adult[MESH]|Animals[MESH]|Basic Helix-Loop-Helix Transcription Factors/physiology[MESH]|Cyclic AMP Response Element-Binding Protein/physiology[MESH]|Drosophila Proteins/physiology[MESH]|Early Growth Response Protein 1/physiology[MESH]|GATA4 Transcription Factor/physiology[MESH]|Genes, Developmental/*physiology[MESH]|Heart Diseases/*etiology[MESH]|Histone Acetyltransferases/physiology[MESH]|Histone Deacetylases/physiology[MESH]|Homeobox Protein Nkx-2.5[MESH]|Homeodomain Proteins/physiology[MESH]|Humans[MESH]|MEF2 Transcription Factors[MESH]|Myogenic Regulatory Factors/physiology[MESH]|NF-kappa B/physiology[MESH]|NFATC Transcription Factors/physiology[MESH]|Serum Response Factor/physiology[MESH]|Smad Proteins/physiology[MESH]|Transcription Factors/genetics/*physiology[MESH] |