suck pdf from google scholar
unlimited free pdf from europmc17157473    free
PDF from PMC    free
html from PMC    free
PDF vom PMID17157473  :  Publisher
suck pdf from library genesis
English Wikipedia

Nephropedia Template TP (

Twit Text


  • DeepDyve
  • Pubget Overpricing


  • lüll
  • Prenatal TCDD exposure predisposes for mammary cancer in rats
  • Jenkins S; Rowell C; Wang J; Lamartiniere CA
  • Reprod Toxicol 2007[Apr]; 23 (3): 391-6
  • Epidemiological data are conflicting in the link between 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure and breast cancer causation. We have hypothesized that timing of exposure to endocrine disruptors, such as TCDD, will alter breast cancer susceptibility. Using a carcinogen induced rat mammary cancer model, we have shown that prenatal exposure to TCDD alters mammary gland differentiation and increases susceptibility for mammary cancer. Investigations into imprinting via DNA methylation mechanisms showed that there were no changes in protein expression in DNA methyltransferases, ER-alpha, ER-beta, GST-pi, or MDGI. Using 2D gels and mass spectrometry, we have found seven proteins to be differentially regulated, including a decrease in superoxide dismutase 1 (SOD1). Down-regulation of SOD1 could provide an environment ill equipped to deal with subsequent free radical exposure. We conclude that prenatal TCDD can predispose for mammary cancer susceptibility in the adult offspring by altering the mammary proteome.
  • |*Prenatal Exposure Delayed Effects[MESH]
  • |Animals[MESH]
  • |Electrophoresis, Gel, Two-Dimensional[MESH]
  • |Environmental Pollutants/toxicity[MESH]
  • |Female[MESH]
  • |Mammary Neoplasms, Animal/*chemically induced/metabolism/pathology[MESH]
  • |Polychlorinated Dibenzodioxins/*toxicity[MESH]
  • |Pregnancy[MESH]
  • |Rats[MESH]
  • |Superoxide Dismutase-1[MESH]
  • |Superoxide Dismutase/metabolism[MESH]





  • *{{pmid17157473}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=17157473 Prenatal TCDD exposure predisposes for mammary cancer in rats ]</b> Reprod Toxicol 2007; 23(3) ; 391-6 Jenkins S; Rowell C; Wang J; Lamartiniere CA

        *17157473*

    Nephropedia PMID record

    Deutsche Wikipedia - im Artikel

    Hier den unten stehenden Textblock hineinkopieren

    Reprod Toxicol

    391 3.23 2007