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 Improving the use of research evidence in guideline development: 15   Disseminating and implementing guidelines Fretheim A; Schunemann HJ; Oxman ADHealth Res Policy Syst  2006[Dec]; 4 (ä): 27BACKGROUND: The World Health Organization (WHO), like many other organisations  around the world, has recognised the need to use more rigorous processes to  ensure that health care recommendations are informed by the best available  research evidence. This is the 15th of a series of 16 reviews that have been  prepared as background for advice from the WHO Advisory Committee on Health  Research to WHO on how to achieve this. OBJECTIVES: In this review we address  strategies for the implementation of recommendations in health care. METHODS: We  examined overviews of systematic reviews of interventions to improve health care  delivery and health care systems prepared by the Cochrane Effective Practice and  Organisation of Care (EPOC) group. We also conducted searches using PubMed and  three databases of methodological studies for existing systematic reviews and  relevant methodological research. We did not conduct systematic reviews  ourselves. Our conclusions are based on the available evidence, consideration of  what WHO and other organisations are doing and logical arguments. KEY QUESTIONS  AND ANSWERS: What should WHO do to disseminate and facilitate the uptake of  recommendations? WHO should choose strategies to implement their guidelines from  among those which have been evaluated positively in the published literature on  implementation research Because the evidence base is weak and modest to moderate  effects, at best, can be anticipated, WHO should promote rigorous evaluations of  implementation strategies. What should be done at headquarters, by regional  offices and in countries? Adaptation and implementation of WHO guidelines should  be done locally, at the national or sub-national level. WHO headquarters and  regional offices should support the development and evaluation of implementation  strategies by local authorities.ä
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