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lüll Chagas disease Teixeira AR; Nitz N; Guimaro MC; Gomes C; Santos-Buch CAPostgrad Med J 2006[Dec]; 82 (974): 788-98Chagas disease is the clinical condition triggered by infection with the protozoan Trypanosoma cruzi. The infection is transmitted by triatomine insects while blood feeding on a human host. Field studies predict that one third of an estimated 18 million T cruzi-infected humans in Latin America will die of Chagas disease. Acute infections are usually asymptomatic, but the ensuing chronic T cruzi infections have been associated with high ratios of morbidity and mortality: Chagas heart disease leads to unexpected death in 37.5% of patients, 58% develop heart failure and die and megacolon or megaoesophagus has been associated with death in 4.5%. The pathogenesis of Chagas disease appears to be related to a parasite-induced mutation of the vertebrate genome. Currently, treatment is unsatisfactory.|*Chagas Disease/etiology/prevention & control/transmission[MESH]|*Trypanosoma cruzi/genetics/pathogenicity[MESH]|Acute Disease[MESH]|Animals[MESH]|Chronic Disease[MESH]|DNA, Kinetoplast/genetics[MESH]|Humans[MESH]|Insect Vectors/parasitology[MESH]|Treatment Failure[MESH]|Triatoma/parasitology[MESH]|Trypanocidal Agents/therapeutic use[MESH] |