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Lipid rafts, detergent-resistant membranes, and raft targeting signals Brown DAPhysiology (Bethesda) 2006[Dec]; 21 (ä): 430-9Lipid rafts are liquid-ordered (l(o)) phase microdomains proposed to exist in biological membranes. Rafts have been widely studied by isolating l(o)-phase detergent-resistant membranes (DRMs) from cells. Recent findings have shown that DRMs are not the same as preexisting rafts, prompting a major revision of the raft model. Nevertheless, raft-targeting signals identified by DRM analysis are often required for protein function, implicating rafts in a variety of cell processes.|Animals[MESH]|Cell Membrane/*physiology[MESH]|Detergents[MESH]|Humans[MESH]|Membrane Microdomains/*physiology[MESH]|Membrane Proteins/physiology[MESH]|Signal Transduction/*physiology[MESH] |
