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Cause of death with bare metal and sirolimus-eluting stents Holmes DR Jr; Moses JW; Schofer J; Morice MC; Schampaert E; Leon MBEur Heart J 2006[Dec]; 27 (23): 2815-22AIMS: Although drug-eluting stents have assumed a dominant role in interventional cardiology, concern has been raised about the potential for long-term adverse outcomes, including death. The aim of the present study was to compare the incidence and cause of death between patients who received sirolimus-eluting or bare metal stents. METHODS AND RESULTS: An integrated analysis was performed on 1748 patients enrolled in four prospective double-blind trials that randomly assigned patients to receive either a sirolimus-eluting or a bare metal stent for treatment of a single de novo coronary stenosis. During a mean follow-up of 2.6+/-0.6 years, 64 patients (3.7%) died. Total mortality was 3.2% among 870 bare metal stent patients and 4.1% among 878 sirolimus-eluting stent patients (P=0.37); there was no difference in cardiac mortality (1.4 vs. 1.3%; P=0.55) or causes of death between these two groups. The predominant cause of death was non-cardiac. Cardiac death was most frequently assigned owing to unwitnessed death. Death due to acute myocardial infarction, congestive heart failure, and stent thrombosis occurred infrequently. CONCLUSION: At a mean follow-up of 2.6 years in percutaneous coronary intervention patients, the predominant cause of death was non-cardiac. There was no significant difference in either the frequency or the cause of death with implantation of either sirolimus-eluting or bare metal stents.|*Stents[MESH]|Aged[MESH]|Cause of Death[MESH]|Coronary Restenosis/*drug therapy/mortality[MESH]|Death, Sudden, Cardiac/etiology[MESH]|Female[MESH]|Heart Failure/etiology[MESH]|Humans[MESH]|Immunosuppressive Agents/*administration & dosage[MESH]|Male[MESH]|Middle Aged[MESH]|Multicenter Studies as Topic[MESH]|Randomized Controlled Trials as Topic[MESH]|Regression Analysis[MESH]|Sirolimus/*administration & dosage[MESH] |
