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  • UVRAG: a new player in autophagy and tumor cell growth
  • Liang C; Feng P; Ku B; Oh BH; Jung JU
  • Autophagy 2007[Jan]; 3 (1): 69-71
  • Autophagy has a well-documented role in the maintenance of homeostasis and the response to stressful environments and it is often deregulated in various human diseases including cancer. The regulation of the Beclin 1-PI3KC3 complex lipid kinase activity is a critical element in the autophagy signaling pathway. Previous studies(1) have demonstrated that Beclin 1-PI3KC3-mediated autophagy is negatively regulated by a proto-oncogene Bcl-2. We have recently identified a novel coiled-coil UVRAG tumor suppressor candidate, which positively engages in Beclin 1-dependent autophagy. UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis. This finding adds a new player to the emerging picture of the autophagy network, under-scoring the importance of the coordinated activity between Bcl-2 and UVRAG in the regulation of Beclin 1-PI3KC3-mediated autophagy and tumor cell control.
  • |Animals[MESH]
  • |Autophagy/*physiology[MESH]
  • |Cell Growth Processes/*physiology[MESH]
  • |Humans[MESH]
  • |Neoplasms/*etiology[MESH]
  • |Tumor Suppressor Proteins/*physiology[MESH]





  • *{{pmid17106237}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=17106237 UVRAG: a new player in autophagy and tumor cell growth ]</b> Autophagy 2007; 3(1) ; 69-71 Liang C; Feng P; Ku B; Oh BH; Jung JU

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    Autophagy

    69 1.3 2007