Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotype Nierodzik ML; Karpatkin SCancer Cell 2006[Nov]; 10 (5): 355-62The association of idiopathic venous thrombosis with occult cancer is generally recognized. However, it has not been fully appreciated that thrombin generated during thrombosis can augment the malignant phenotype. Thrombin activates tumor cell adhesion to platelets, endothelial cells, and subendothelial matrix proteins; enhances tumor cell growth; increases tumor cell seeding and spontaneous metastasis; and stimulates tumor cell angiogenesis. These mechanisms are reviewed. Evidence is also presented to support the hypothesis that thrombin serves to preserve dormant tumor cells in individuals, preventing host eradication. It is proposed that tumor malignancy may be regulated by a procoagulant/anticoagulant axis.|*Neovascularization, Pathologic[MESH]|Animals[MESH]|Anticoagulants/therapeutic use[MESH]|Blood Platelets/metabolism[MESH]|Cell Adhesion/physiology[MESH]|Humans[MESH]|Lung/pathology[MESH]|Neoplasm Metastasis[MESH]|Neoplasms/drug therapy/*metabolism/*pathology[MESH]|Phenotype[MESH]|Randomized Controlled Trials as Topic[MESH]|Receptor, PAR-1/metabolism[MESH]|Thrombin/*metabolism[MESH]|Venous Thrombosis[MESH] |